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Sox2 promotes survival of satellite glial cells in vitro
https://repository.lib.tottori-u.ac.jp/records/7108
https://repository.lib.tottori-u.ac.jp/records/710863c5b5ed-b1f2-4596-956f-cd99ab66dc1c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bbrc646(1)_269.pdf (515.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-15 | |||||
| タイトル | ||||||
| タイトル | Sox2 promotes survival of satellite glial cells in vitro | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Sox2 | |||||
| キーワード | ||||||
| 主題 | Satellite glial cell | |||||
| キーワード | ||||||
| 主題 | Apoptosis | |||||
| キーワード | ||||||
| 主題 | Culture | |||||
| キーワード | ||||||
| 主題 | ErbB | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Sox2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Satellite glial cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Apoptosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Culture | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ErbB | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Koike, Taro
× Koike, Taro× Wakabayashi, Taketoshi× Mori, Tetsuji× Hirahara, Yukie× Yamada, Hisao |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Sox2 is a transcriptional factor expressed in neural stem cells. It is known that Sox2 regulates cell differentiation, proliferation and survival of the neural stem cells. Our previous study showed that Sox2 is expressed in all satellite glial cells of the adult rat dorsal root ganglion. In this study, to examine the role of Sox2 in satellite glial cells, we establish a satellite glial cell-enriched culture system. Our culture method succeeded in harvesting satellite glial cells with the somata of neurons in the dorsal root ganglion. Using this culture system, Sox2 was downregulated by siRNA against Sox2. The knockdown of Sox2 downregulated ErbB2 and ErbB3 mRNA at 2 and 4 days after siRNA treatment. MAPK phosphorylation, downstream of ErbB, was also inhibited by Sox2 knockdown. Because ErbB2 and ErbB3 are receptors that support the survival of glial cells in the peripheral nervous system, apoptotic cells were also counted. TUNEL-positive cells increased at 5 days after siRNA treatment. These results suggest that Sox2 promotes satellite glial cell survival through the MAPK pathway via ErbB receptors. | |||||
| 書誌情報 |
Biochemical and biophysical research communications en : Biochemical and biophysical research communications 巻 464, 号 1, p. 269-274, 発行日 2015-08-14 |
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| 雑誌内区分 | ||||||
| 値 | Short communication | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006291X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00564395 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbrc.2015.06.141 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2015 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 情報源 | ||||||
| 関連名称 | Koike T., Wakabayashi T., Mori T., Hirahara Y., Yamada H. Sox2 promotes survival of satellite glial cells in vitro. Biochemical and Biophysical Research Communications(2015), 464 (1) , pp. 269-274. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0006291X15301959 | |||||
| 関連名称 | https://www.sciencedirect.com/science/article/pii/S0006291X15301959 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
