{"_buckets": {"deposit": "44e1c343-f8da-4724-a622-087c4a241e61"}, "_deposit": {"created_by": 1, "id": "7110", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "7110"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00007110", "sets": ["9", "12"]}, "author_link": ["26301", "26297", "4750", "26302", "4929", "4904", "26300", "26298", "26299"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "Biology Open"}, {"bibliographic_title": "Biology Open", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Microtubule-associated protein A1/B1-light chain 3 (LC3)-associated phagocytosis (LAP) is a type of non-canonical autophagy that regulates phagosome maturation in macrophages. However, the role and regulatory mechanism of LAP remain largely unknown. Recently, the membrane occupation and recognition nexus repeat-containing-2 (MORN2) was identified as a key component of LAP for the efficient formation of LC3-recruiting phagosomes. To characterize MORN2 and elucidate its function in LAP, we established a MORN2-overexpressing macrophage line. At a steady state, MORN2 was partially cleaved by the ubiquitin-proteasome system. MORN2 overexpression promoted not only LC3-II production but also LAP phagosome (LAPosome) acidification during Escherichia coli uptake. Furthermore, the formation of LAPosomes containing the yeast cell wall component zymosan was enhanced in MORN2-overexpressing cells and depended on reactive oxygen species (ROS). Finally, MORN2-mediated LAP was regulated by plasma membrane-localized soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) such as SNAP-23 and syntaxin 11. Taken together, these findings demonstrate that MORN2, whose expression is downregulated via proteasomal digestion, is a limiting factor for LAP, and that membrane trafficking by SNARE proteins is involved in MORN2-mediated LAP.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "The Company of Biologists"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1242/bio.051029", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Morita Maya, Kajiye Mayu, Sakurai Chiye, et al. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Biology open. 2020. 9(6). doi: 10.1242/bio.051029"}]}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://journals.biologists.com/bio/article/9/6/bio051029/222866"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://journals.biologists.com/bio/article/9/6/bio051029/222866", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2020. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and repr"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "20466390", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "12858"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": ";;Biology Open"}]}, "item_10001_text_33": {"attribute_name": "著者所属（英）", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", 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