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Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation
https://repository.lib.tottori-u.ac.jp/records/7187
https://repository.lib.tottori-u.ac.jp/records/7187d91b283b-8117-4a4c-b5b3-4ce4c18b788d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ejn36(9)_3184.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-08 | |||||
| タイトル | ||||||
| タイトル | Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | adult mouse SVZ | |||||
| キーワード | ||||||
| 主題 | cell cycle | |||||
| キーワード | ||||||
| 主題 | neurogenesis | |||||
| キーワード | ||||||
| 主題 | precursor | |||||
| キーワード | ||||||
| 主題 | seizure | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | adult mouse SVZ | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cell cycle | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neurogenesis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | precursor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | seizure | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Mori, Tetsuji
× Mori, Tetsuji× Wakabayashi, Taketoshi× Hirahara, Yukie× Takamori, Yasuharu× Kurokawa, Kiyoshi× Yamada, Hisao |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy & Cell Science, Kansai Medical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Adult neurogenesis in the subgranular zone of the hippocampus (SGZ) is enhanced by excess as well as mild neuronal excitation, such as chemoconvulsant‐induced brief seizures. Because most studies of neurogenesis after seizures have focused on the SGZ, the threshold of neuronal excitation required to enhance neurogenesis in the subventricular zone (SVZ) is not clear. Therefore, we examined the responses of SVZ precursors to brief generalized clonic seizures induced by a single administration of the chemoconvulsant pentylenetetrazole (PTZ). Cell cycle progression of precursors was analysed by systemic administration of thymidine analogues. We found that brief seizures immediately resulted in cell cycle retardation in the SVZ. However, the same effect was not seen in the SGZ. This initial cell cycle retardation in the SVZ was followed by enhanced cell cycle re‐entry after the first round of mitosis, leading to precursor pool expansion, but the cell cycle retardation and expansion of the precursor pool were transient. Cell cycle progression in the PTZ‐treated group returned to normal after one cell cycle. The numbers of precursors in the SVZ and new neurons in the olfactory bulb, which are descendants of SVZ precursors, were not significantly different from those in control mice more than 2 days after seizures. Because similar effects were observed following electroconvulsive seizures, these responses are likely to be general effects of brief seizures. These results suggest that neurogenesis in the SVZ is more tightly regulated and requires stronger stimuli to be modified than that in the SGZ. | |||||
| 書誌情報 |
European journal of neuroscience en : European journal of neuroscience 巻 36, 号 9, p. 3184-3193, 発行日 2012-11-30 |
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| 出版者 | ||||||
| 出版者 | Federation of European Neuroscience Societies and Blackwell Publishing Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14609568 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11622970 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1460-9568.2012.08244.x | |||||
| 権利 | ||||||
| 権利情報 | © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd | |||||
| 情報源 | ||||||
| 関連名称 | This is the pre-peer reviewed version of the following article: Mori, T., Wakabayashi, T., Hirahara, Y., Takamori, Y., Koike, T., Kurokawa, K. and Yamada, H. (2012), Differential responses of endogenous adult mouse neural precursors to excess neuronal exc | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x | |||||
| 関連名称 | https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
