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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
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  2. 学術雑誌論文

Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation

https://repository.lib.tottori-u.ac.jp/records/7187
https://repository.lib.tottori-u.ac.jp/records/7187
d91b283b-8117-4a4c-b5b3-4ce4c18b788d
名前 / ファイル ライセンス アクション
ejn36(9)_3184.pdf ejn36(9)_3184.pdf (2.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-08
タイトル
タイトル Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation
言語 en
言語
言語 eng
キーワード
主題 adult mouse SVZ
キーワード
主題 cell cycle
キーワード
主題 neurogenesis
キーワード
主題 precursor
キーワード
主題 seizure
キーワード
言語 en
主題 adult mouse SVZ
キーワード
言語 en
主題 cell cycle
キーワード
言語 en
主題 neurogenesis
キーワード
言語 en
主題 precursor
キーワード
言語 en
主題 seizure
資源タイプ
資源タイプ journal article
著者 Mori, Tetsuji

× Mori, Tetsuji

WEKO 2308
e-Rad 30285043
研究者総覧鳥取大学 100001237

en Mori, Tetsuji

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Wakabayashi, Taketoshi

× Wakabayashi, Taketoshi

WEKO 26596

en Wakabayashi, Taketoshi

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Hirahara, Yukie

× Hirahara, Yukie

WEKO 26597

en Hirahara, Yukie

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Takamori, Yasuharu

× Takamori, Yasuharu

WEKO 26598

en Takamori, Yasuharu

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Kurokawa, Kiyoshi

× Kurokawa, Kiyoshi

WEKO 26599

en Kurokawa, Kiyoshi

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Yamada, Hisao

× Yamada, Hisao

WEKO 26600

en Yamada, Hisao

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著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
著者所属(英)
言語 en
値 Department of Anatomy & Cell Science, Kansai Medical University
抄録
内容記述タイプ Other
内容記述 Adult neurogenesis in the subgranular zone of the hippocampus (SGZ) is enhanced by excess as well as mild neuronal excitation, such as chemoconvulsant‐induced brief seizures. Because most studies of neurogenesis after seizures have focused on the SGZ, the threshold of neuronal excitation required to enhance neurogenesis in the subventricular zone (SVZ) is not clear. Therefore, we examined the responses of SVZ precursors to brief generalized clonic seizures induced by a single administration of the chemoconvulsant pentylenetetrazole (PTZ). Cell cycle progression of precursors was analysed by systemic administration of thymidine analogues. We found that brief seizures immediately resulted in cell cycle retardation in the SVZ. However, the same effect was not seen in the SGZ. This initial cell cycle retardation in the SVZ was followed by enhanced cell cycle re‐entry after the first round of mitosis, leading to precursor pool expansion, but the cell cycle retardation and expansion of the precursor pool were transient. Cell cycle progression in the PTZ‐treated group returned to normal after one cell cycle. The numbers of precursors in the SVZ and new neurons in the olfactory bulb, which are descendants of SVZ precursors, were not significantly different from those in control mice more than 2 days after seizures. Because similar effects were observed following electroconvulsive seizures, these responses are likely to be general effects of brief seizures. These results suggest that neurogenesis in the SVZ is more tightly regulated and requires stronger stimuli to be modified than that in the SGZ.
書誌情報 European journal of neuroscience
en : European journal of neuroscience

巻 36, 号 9, p. 3184-3193, 発行日 2012-11-30
出版者
出版者 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
ISSN
収録物識別子タイプ ISSN
収録物識別子 14609568
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11622970
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1111/j.1460-9568.2012.08244.x
権利
権利情報 © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
情報源
関連名称 This is the pre-peer reviewed version of the following article: Mori, T., Wakabayashi, T., Hirahara, Y., Takamori, Y., Koike, T., Kurokawa, K. and Yamada, H. (2012), Differential responses of endogenous adult mouse neural precursors to excess neuronal exc
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x
関連名称 https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x
著者版フラグ
出版タイプ AM
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