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CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice
https://repository.lib.tottori-u.ac.jp/records/7195
https://repository.lib.tottori-u.ac.jp/records/71952964ea50-e5ee-4115-a869-070ad162705d
| 名前 / ファイル | ライセンス | アクション |
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fi_fimmu_2020_00775.pdf (4.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-11-24 | |||||
| タイトル | ||||||
| タイトル | CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | tissue-resident memory T cells | |||||
| キーワード | ||||||
| 主題 | helper T cells | |||||
| キーワード | ||||||
| 主題 | killer T cells | |||||
| キーワード | ||||||
| 主題 | local skin memory | |||||
| キーワード | ||||||
| 主題 | contact hypersensitivity | |||||
| キーワード | ||||||
| 主題 | allergic contact dermatitis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tissue-resident memory T cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | helper T cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | killer T cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | local skin memory | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | contact hypersensitivity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | allergic contact dermatitis | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
村田, 暁彦
× 村田, 暁彦× 林, 眞一 |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten. This “local skin memory” (LSM) in healed skin was maintained for a prolonged period of time and mediated by skin CD8+-resident memory T (TRM) cells in C57BL/6 mice. However, the number of CD4+ T cells is elevated in ACD-healed human skin, and the contribution of CD4+ TRM cells to the formation of LSM currently remains unclear. We herein demonstrated that immediately after CHS subsided, the healed skin in BALB/c mice showed an accumulation of hapten-specific CD4+ and CD8+ TRM cells, with a predominance of CD4+ TRM cells. The presence of CD4+ or CD8+ TRM cells in the healed skin was sufficient for the induction of a flare-up reaction upon a re-challenge. The CD4+ and CD8+ TRM cells both produced interferon-g and tumor necrosis factor early after the re-challenge. Moreover, while CD8+ TRM cells gradually decreased over time and were eventually lost from the healed skin at 40–51 weeks after the resolution of CHS, the CD4+ TRM cell numbers remained elevated during this period. The present results indicate that the long-term maintenance of LSM is mediated by CD4+ TRM cells, and thus CD4+ TRM cells are an important target for the treatment of recurrent human ACD. | |||||
| 書誌情報 |
FRONTIERS IN IMMUNOLOGY en : FRONTIERS IN IMMUNOLOGY 巻 11, 発行日 2020-05-19 |
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| 出版者 | ||||||
| 出版者 | International Union of Immunological Societies | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 16643224 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fimmu.2020.00775 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2020 Murata and Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and th | |||||
| 情報源 | ||||||
| 関連名称 | Murata Akihiko, Hayashi Shin-Ichi. CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice. FRONTIERS IN IMMUNOLOGY. 2020. 11. doi:10.3389/fimmu.2020.00775 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full | |||||
| 関連名称 | https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
