{"_buckets": {"deposit": "ac0d6775-5019-444b-b0ba-fe36eb5a418b"}, "_deposit": {"created_by": 10, "id": "7195", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "7195"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00007195", "sets": ["12", "9"]}, "author_link": ["2371", "4921"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05-19", "bibliographicIssueDateType": "Issued"}, "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "FRONTIERS IN IMMUNOLOGY"}, {"bibliographic_title": "FRONTIERS IN IMMUNOLOGY", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten. This “local skin memory” (LSM) in healed skin was maintained for a prolonged period of time and mediated by skin CD8+-resident memory T (TRM) cells in C57BL/6 mice. However, the number of CD4+ T cells is elevated in ACD-healed human skin, and the contribution of CD4+ TRM cells to the formation of LSM currently remains unclear. We herein demonstrated that immediately after CHS subsided, the healed skin in BALB/c mice showed an accumulation of hapten-specific CD4+ and CD8+ TRM cells, with a predominance of CD4+ TRM cells. The presence of CD4+ or CD8+ TRM cells in the healed skin was sufficient for the induction of a flare-up reaction upon a re-challenge. The CD4+ and CD8+ TRM cells both produced interferon-g and tumor necrosis factor early after the re-challenge. Moreover, while CD8+ TRM cells gradually decreased over time and were eventually lost from the healed skin at 40–51 weeks after the resolution of CHS, the CD4+ TRM cell numbers remained elevated during this period. The present results indicate that the long-term maintenance of LSM is mediated by CD4+ TRM cells, and thus CD4+ TRM cells are an important target for the treatment of recurrent human ACD.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "International Union of Immunological Societies"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3389/fimmu.2020.00775", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Murata Akihiko, Hayashi Shin-Ichi. CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice. FRONTIERS IN IMMUNOLOGY. 2020. 11. doi:10.3389/fimmu.2020.00775"}]}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2020 Murata and Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and th"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "16643224", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "9776"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": ";;FRONTIERS IN IMMUNOLOGY"}]}, "item_10001_text_33": {"attribute_name": "著者所属（英）", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "村田, 暁彦"}, {"creatorName": "ムラタ, アキヒコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Murata, Akihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2371", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90624221", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90624221"}, {"nameIdentifier": "100000266", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000266_ja.html"}]}, {"creatorNames": [{"creatorName": "林, 眞一"}, {"creatorName": "ハヤシ, シンイチ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hayashi, Shin-ichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4921", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50208617", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50208617"}, {"nameIdentifier": "100000221", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000221_ja.html"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "fi_fimmu_2020_00775.pdf", "filesize": [{"value": "4.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright © 2020 Murata and Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 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