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Dark Rearing Promotes the Recovery of Visual Cortical Responses but Not the Morphology of Geniculocortical Axons in Amblyopic Cat
https://repository.lib.tottori-u.ac.jp/records/7197
https://repository.lib.tottori-u.ac.jp/records/7197d5707046-6863-41f5-a0b1-cd296e9d3bd8
| 名前 / ファイル | ライセンス | アクション |
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fnc15_fncir_2021_637638.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-08 | |||||
| タイトル | ||||||
| タイトル | Dark Rearing Promotes the Recovery of Visual Cortical Responses but Not the Morphology of Geniculocortical Axons in Amblyopic Cat | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | visual cortex | |||||
| キーワード | ||||||
| 主題 | geniculocortical axons | |||||
| キーワード | ||||||
| 主題 | dark rearing | |||||
| キーワード | ||||||
| 主題 | ocular dominance | |||||
| キーワード | ||||||
| 主題 | monocular deprivation | |||||
| キーワード | ||||||
| 主題 | amblyopia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | visual cortex | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | geniculocortical axons | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dark rearing | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ocular dominance | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | monocular deprivation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | amblyopia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
カメヤマ, カツロウ
× カメヤマ, カツロウ× 畠, 義郎× Gotou, Takahiro× Kobayashi, Ayane× Okamura, Kayoko× Ando, Takahiko× Terata, Keiko× Yamada, Chihiro× Ohta, Hiroyuki× Morizane, Ayaka |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Integrative Bioscience, Tottori University Graduate School of Medical Sciences / Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Monocular deprivation (MD) of vision during early postnatal life induces amblyopia, and most neurons in the primary visual cortex lose their responses to the closed eye. Anatomically, the somata of neurons in the closed-eye recipient layer of the lateral geniculate nucleus (LGN) shrink and their axons projecting to the visual cortex retract. Although it has been difficult to restore visual acuity after maturation, recent studies in rodents and cats showed that a period of exposure to complete darkness could promote recovery from amblyopia induced by prior MD. However, in cats, which have an organization of central visual pathways similar to humans, the effect of dark rearing only improves monocular vision and does not restore binocular depth perception. To determine whether dark rearing can completely restore the visual pathway, we examined its effect on the three major concomitants of MD in individual visual neurons, eye preference of visual cortical neurons and soma size and axon morphology of LGN neurons. Dark rearing improved the recovery of visual cortical responses to the closed eye compared with the recovery under binocular conditions. However, geniculocortical axons serving the closed eye remained retracted after dark rearing, whereas reopening the closed eye restored the soma size of LGN neurons. These results indicate that dark rearing incompletely restores the visual pathway, and thus exerts a limited restorative effect on visual function. | |||||
| 書誌情報 |
FRONTIERS IN NEURAL CIRCUITS en : FRONTIERS IN NEURAL CIRCUITS 巻 15, 発行日 2021-04-16 |
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| 出版者 | ||||||
| 出版者 | Frontiers Media | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fncir.2021.637638 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2021 Gotou, Kameyama, Kobayashi, Okamura, Ando, Terata, Yamada, Ohta, Morizane and Hata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in o | |||||
| 情報源 | ||||||
| 関連名称 | Gotou Takahiro, Kameyama Katsuro, Kobayashi Ayane, et al. Dark Rearing Promotes the Recovery of Visual Cortical Responses but Not the Morphology of Geniculocortical Axons in Amblyopic Cat. FRONTIERS IN NEURAL CIRCUITS. 2021. 15. doi:10.3389/fncir.2021.637 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fncir.2021.637638/full | |||||
| 関連名称 | https://www.frontiersin.org/articles/10.3389/fncir.2021.637638/full | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 16625110 | |||||
