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Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex
https://repository.lib.tottori-u.ac.jp/records/7206
https://repository.lib.tottori-u.ac.jp/records/720690594ebf-a7ba-4550-bc43-e8a70e0e2c01
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ibror5_99.pdf (13.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-16 | |||||
| タイトル | ||||||
| タイトル | Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lamins | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neurons | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glial cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Adult rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cerebral cortex | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lamins | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Neurons | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Glial cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Adult rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cerebral cortex | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takamori, Yasuharu
× Takamori, Yasuharu× Hirahara, Yukie× Wakabayashi, Taketoshi× Mori, Tetsuji× Koike, Taro× Kataoka, Yosky× Tamura, Yasuhisa× Kurebayashi, Shuji× Kurokawa, Kiyoshi× Yamada, Hisao |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University / Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research / Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research / Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University / Department of School Education Research, Shizuoka University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University / Department of Human Health Science, Osaka international University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Anatomy and Cell Science, Kansai Medical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate somatic lamins A and C. Mutations in lamin genes have been linked to many human hereditary diseases, including neurodegenerative disorders. Knowledge about lamins in the nervous system has been accumulated recently, but a precise analysis of lamin subtypes in glial cells has not yet been reported. In this study we investigated the composition of lamin subtypes in neurons, astrocytes, oligodendrocyte-lineage cells, and microglia in the adult rat cerebral cortex using an immunohistochemical staining method. Lamin A was not observed in neurons and glial cells. Lamin C was observed in astrocytes, mature oligodendrocytes and neurons, but not observed in oligodendrocyte progenitor cells. Microglia also did not stain positive for lamin C which differed from macrophages, with lamin C positive. Lamin B1 and B2 were observed in all glial cells and neurons. Lamin B1 was intensely positive in oligodendrocyte progenitor cells compared with other glial cells and neurons. Lamin B2 was weakly positive in all glial cells compared to neurons. Our current study might provide useful information to reveal how the onset mechanisms of human neurodegenerative diseases are associated with mutations in genes for nuclear lamin proteins. | |||||
| 書誌情報 |
IBRO Reports en : IBRO Reports 巻 5, p. 99-109, 発行日 2018-11-05 |
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| 雑誌内区分 | ||||||
| 値 | Research article | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 24518301 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ibror.2018.11.001 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | TAKAMORI, Yasuharu, et al. Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex. IBRO reports, 2018, 5: 99-109. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S2451830118300578 | |||||
| 関連名称 | https://www.sciencedirect.com/science/article/pii/S2451830118300578 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
