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Kit-independent mast cell adhesion mediated by Notch
https://repository.lib.tottori-u.ac.jp/records/7213
https://repository.lib.tottori-u.ac.jp/records/72138a560b0d-af00-45bb-a8c8-80555c50d682
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ii31(2)_69.pdf (7.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-11-24 | |||||
| タイトル | ||||||
| タイトル | Kit-independent mast cell adhesion mediated by Notch | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Delta-like | |||||
| キーワード | ||||||
| 主題 | Jagged | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Delta-like | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Jagged | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
村田, 暁彦
× 村田, 暁彦× 吉野, 三也× 林, 眞一× Hikosaka, Mari× Zhou, Lan |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathology, Case Western Reserve University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments. | |||||
| 書誌情報 |
INTERNATIONAL IMMUNOLOGY en : INTERNATIONAL IMMUNOLOGY 巻 31, 号 2, p. 69-79, 発行日 2019-02 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09538178 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/intimm/dxy067 | |||||
| 権利 | ||||||
| 権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in INTERNATIONAL IMMUNOLOGY following peer review. The version of record Akihiko Murata, Mari Hikosaka, Miya Yoshino, Lan Zhou, Shin-Ichi Hayashi, Kit-independent mas | |||||
| 情報源 | ||||||
| 関連名称 | Murata Akihiko, Hikosaka Mari, Yoshino Miya, et al. Kit-independent mast cell adhesion mediated by Notch. INTERNATIONAL IMMUNOLOGY. 2019. 31(2). 69-79. doi:10.1093/intimm/dxy067 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/intimm/article/31/2/69/5123694 | |||||
| 関連名称 | https://academic.oup.com/intimm/article/31/2/69/5123694 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| EISSN | ||||||
| 値 | 14602377 | |||||
