WEKO3
アイテム
HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma
https://repository.lib.tottori-u.ac.jp/records/7227
https://repository.lib.tottori-u.ac.jp/records/72279225a67c-5158-40f6-8fb4-c968d446e07a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ijms20_ijms20225714.pdf (2.1 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-08 | |||||
| タイトル | ||||||
| タイトル | HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | URI1 | |||||
| キーワード | ||||||
| 主題 | HBx | |||||
| キーワード | ||||||
| 主題 | c-MYC | |||||
| キーワード | ||||||
| 主題 | HBV-related hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題 | E-box | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | URI1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | HBx | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | c-MYC | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | HBV-related hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | E-box | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
土谷, 博之
× 土谷, 博之× 網崎, 正孝× 本城, 総一郎× 藤原, 義之× 汐田, 剛史× Takenaga, Ai |
|||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Unconventional prefoldin RNA polymerase II subunit 5 interactor (URI1) has emerged as an oncogenic driver in hepatocellular carcinoma (HCC). Although the hepatitis B virus (HBV) represents the most common etiology of HCC worldwide, it is unknown whether URI1 plays a role in HBV-related HCC (HCC-B). In the present study, we investigated URI1 expression and its underlying mechanism in HCC-B tissues and cell lines. URI1 gene-promoter activity was determined by a luciferase assay. Human HCC-B samples were used for a chromatin immunoprecipitation assay. We found that c-MYC induced URI1 expression and activated the URI1 promoter through the E-box in the promoter region while the HBx protein significantly enhanced it. The positivity of URI1 expression was significantly higher in HCC-B tumor tissues than in non-HBV-related HCC tumor tissues, suggesting that a specific mechanism underlies URI1 expression in HCC-B. In tumor tissues from HCC-B patients, a significantly higher level of c-MYC was recruited to the E-box than in non-tumor tissues. These results suggest that HBx and c-MYC are involved in URI1 expression in HCC-B. URI1 expression may play important roles in the development and progression of HCC-B because HBx and c-MYC are well-known oncogenic factors in the virus and host, respectively. | |||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 20, 号 22, 発行日 2019-11 |
|||||
| 出版者 | ||||||
| 出版者 | MDPI | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/ijms20225714 | |||||
| 権利 | ||||||
| 権利情報 | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | Tsuchiya Hiroyuki, Amisaki Masataka, Takenaga Ai, et al. HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019. 20(22). doi:10.3390/ijms20225714 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/1422-0067/20/22/5714 | |||||
| 関連名称 | https://www.mdpi.com/1422-0067/20/22/5714 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| EISSN | ||||||
| 値 | 14220067 | |||||
