{"_buckets": {"deposit": "35e9d0b7-1a3d-4c7b-a369-bd623b296231"}, "_deposit": {"created_by": 10, "id": "7227", "owners": [10], "pid": {"revision_id": 0, "type": "depid", "value": "7227"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00007227", "sets": ["12", "9"]}, "author_link": ["4866", "95", "780", "377", "3368", "26772"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "22", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES"}, {"bibliographic_title": "INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Unconventional prefoldin RNA polymerase II subunit 5 interactor (URI1) has emerged as an oncogenic driver in hepatocellular carcinoma (HCC). Although the hepatitis B virus (HBV) represents the most common etiology of HCC worldwide, it is unknown whether URI1 plays a role in HBV-related HCC (HCC-B). In the present study, we investigated URI1 expression and its underlying mechanism in HCC-B tissues and cell lines. URI1 gene-promoter activity was determined by a luciferase assay. Human HCC-B samples were used for a chromatin immunoprecipitation assay. We found that c-MYC induced URI1 expression and activated the URI1 promoter through the E-box in the promoter region while the HBx protein significantly enhanced it. The positivity of URI1 expression was significantly higher in HCC-B tumor tissues than in non-HBV-related HCC tumor tissues, suggesting that a specific mechanism underlies URI1 expression in HCC-B. In tumor tissues from HCC-B patients, a significantly higher level of c-MYC was recruited to the E-box than in non-tumor tissues. These results suggest that HBx and c-MYC are involved in URI1 expression in HCC-B. URI1 expression may play important roles in the development and progression of HCC-B because HBx and c-MYC are well-known oncogenic factors in the virus and host, respectively.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/ijms20225714", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Tsuchiya Hiroyuki, Amisaki Masataka, Takenaga Ai, et al. HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019. 20(22). doi:10.3390/ijms20225714"}]}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.mdpi.com/1422-0067/20/22/5714"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.mdpi.com/1422-0067/20/22/5714", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "9460"}]}, "item_10001_text_26": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_text_value": "14220067"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": ";;INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES"}]}, "item_10001_text_33": {"attribute_name": "著者所属（英）", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "土谷, 博之"}, {"creatorName": "ツチヤ, ヒロユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Tsuchiya, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4866", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00403402", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00403402"}, {"nameIdentifier": "100001720", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100001720_ja.html"}]}, {"creatorNames": [{"creatorName": "網崎, 正孝"}, {"creatorName": "アミサキ, マサタカ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Amisaki, Masataka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "95", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40790374", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40790374"}]}, {"creatorNames": [{"creatorName": "本城, 総一郎"}, {"creatorName": "ホンジョウ, ソウイチロウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Honjo, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "780", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "100000247", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000247_ja.html"}]}, {"creatorNames": [{"creatorName": "藤原, 義之"}, {"creatorName": "フジワラ, ヨシユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Fujiwara, Yoshiyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "377", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40314330", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40314330"}, {"nameIdentifier": "100001755", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100001755_ja.html"}]}, {"creatorNames": [{"creatorName": "汐田, 剛史"}, {"creatorName": "シオタ, ゴウシ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Shiota, Goshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3368", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70263457", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70263457"}, {"nameIdentifier": "100000303", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000303_ja.html"}]}, {"creatorNames": [{"creatorName": "Takenaga, Ai", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "26772", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ijms20_ijms20225714.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 by the authors. 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