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Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules
https://repository.lib.tottori-u.ac.jp/records/7229
https://repository.lib.tottori-u.ac.jp/records/72295288d3ce-4a93-4a42-95ff-ebb0ad00f12d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ijms-21-00190.pdf (2.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-03-17 | |||||
| タイトル | ||||||
| タイトル | Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | SGLT2 inhibitor | |||||
| キーワード | ||||||
| 主題 | ER stress | |||||
| キーワード | ||||||
| 主題 | lipotoxicity | |||||
| キーワード | ||||||
| 主題 | steatonephropathy | |||||
| キーワード | ||||||
| 主題 | ectopic fat accumulation | |||||
| キーワード | ||||||
| 主題 | NASH | |||||
| キーワード | ||||||
| 主題 | NAFLD | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | SGLT2 inhibitor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ER stress | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lipotoxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | steatonephropathy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ectopic fat accumulation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | NASH | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | NAFLD | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
高田, 知朗
× 高田, 知朗× 杉原, 誉明× 的野, 智光× Koda, Masahiko× 福田, 佐登子× 磯本, 一× Hosokawa, Kohshiro× Koda, Masahiko× Kanda, Tsutomu× Taniguchi, Sosuke× Ida, Ayami× Mae, Yukari× Yamamoto, Marie× Iyama, Takuji |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University / These authors contributed equally to this work. | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University / These authors contributed equally to this work. | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Hino Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health burdens closely related to metabolic syndrome. A link between CKD and NASH has been assumed; however, the underlying mechanism is still unknown. Ectopic lipid deposition (ELD) in the hepatocyte results in endoplasmic reticulum (ER) stress, which plays an important role in the development of steatohepatitis. ELD is also assumed to play a role in the development of kidney injury. We aimed to investigate the role of ELD and ER stress in the development of CKD, and evaluate the efficacy of a sodium glucose cotransporter-2 inhibitor, ipragliflozin. Methods: Male FLS-ob/ob mice that closely imitate the pathophysiology of NASH were treated with vehicle or ipragliflozin. Metabolic characteristics, histology of the kidney, ER stress, and apoptotic signals were evaluated. Results: The serum triglyceride was significantly lower in mice treated with ipragliflozin. Ipragliflozin reduced ELD in renal tubules. Ipragliflozin also reduced the expression levels of GRP78 and CHOP, apoptotic cells, and interstitial fibrosis. Conclusions: ELD induced kidney injury through ER stress. Ipragliflozin improved the pathogenesis of CKD by reducing ELD and ER stress in NASH-model mice. Our results suggest ipragliflozin has therapeutic effect on CKD in NASH. | |||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 21, 号 1, 発行日 2020-01 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12038549 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/ijms21010190 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | Hosokawa Kohshiro, Takata Tomoaki, Sugihara Takaaki, et al. Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. 21(1). doi:10 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/1422-0067/21/1/190 | |||||
| 関連名称 | https://www.mdpi.com/1422-0067/21/1/190 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 14220067 | |||||
