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Smooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model
https://repository.lib.tottori-u.ac.jp/records/7247
https://repository.lib.tottori-u.ac.jp/records/724730065f9c-273c-4af1-9c57-7328d8d8d930
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jcs11_s13019-016-0508-x.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2021-09-08 | |||||||||||||||||||||||
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| タイトル | Smooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Cell sheet | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Smooth muscle cells | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Myocardial infarction | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Cell survival | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | Cell sheet | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | Smooth muscle cells | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | Myocardial infarction | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | Cell survival | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
原田, 真吾
× 原田, 真吾× 中村, 嘉伸
WEKO
2502
× 白谷, 卓× 藤原, 義和× 岸本, 祐一郎
WEKO
1563
× 大月, 優貴× 岸本, 諭× 山本, 康孝× 久留, 一郎× 西村, 元延
WEKO
2647
× Onohara, Takeshi |
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| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine / Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Background: We examined whether a vascular smooth muscle cell (SMC) sheet is effective in the treatment of a rat myocardial infarction (MI) model. Methods: We examined the effect of SMC sheet on the cardiac function and cardiac remodeling in a rat MI model in comparison with their effect of dermal fibroblast (DFB) sheet in vivo. Furthermore, we estimated the apoptosis and secretion of angiogenic factor of SMC under hypoxic condition in comparison with DFB. Seven days after MI, monolayer cell sheets were transplanted on the infarcted area (SMC transplantation group, SMC-Tx; DFB transplantation group, DFB-Tx; no cell sheet transplantation group, Untreated; neither MI nor cell sheet transplantation group, Sham). We evaluated cardiac function by echocardiogram, degree of cardiac remodeling by histological examination, and secretion of angiogenic growth factor by enzyme immunoassay. Results: Twenty-eight days after transplantation, SMC-Tx showed the following characteristics compared with the other groups: 1) significantly greater fractional area shortening (SMC-Tx, 32.3 ± 2.1 %; DFB-Tx, 23.3 ± 2.1 %; untreated, 25.1 ± 2.6 %), 2) suppressed left ventricular dilation, smaller scar expansion, and preserved wall thickness of the area at risk and the posterior wall, 3) decreased fibrosis, preserved myocardium in the scar area, and greater number of arterioles in border-zone, 4) tight attachment of SMC sheets on the scarred myocardium, and less apoptotic cell death. In in vitro experiments, SMCs secreted higher amounts of basic fibroblast growth factor (SMC, 157.7 ± 6.4 pg/ml; DFB, 3.1 ± 1.0 pg/ml), and showed less apoptotic cell death under hypoxia. Conclusions: Our results illustrate that transplantation of SMC sheets inhibited the progression of cardiac remodeling and improve cardiac function. These beneficial effects may be due to superior SMC survival. | |||||||||||||||||||||||
| 書誌情報 |
JOURNAL OF CARDIOTHORACIC SURGERY en : JOURNAL OF CARDIOTHORACIC SURGERY 巻 11, 発行日 2016-08-05 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | BioMed Central Ltd. | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 17498090 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1186/s13019-016-0508-x | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in an | |||||||||||||||||||||||
| 情報源 | ||||||||||||||||||||||||
| 関連名称 | Harada Shingo, Nakamura Yoshinobu, Shiraya Suguru, et al. Smooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model. JOURNAL OF CARDIOTHORACIC SURGERY. 2016. 11. doi:10.1186/s13 | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-016-0508-x | |||||||||||||||||||||||
| 関連名称 | https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-016-0508-x | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
