| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-09-15 |
| タイトル |
|
|
言語 |
en |
|
タイトル |
Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
C-peptide |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Glucagon stimulation test |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Meal tolerance test |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
C-peptide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glucagon stimulation test |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Meal tolerance test |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
藤岡, 洋平
大倉, 毅
角, 啓佑
松澤, 和彦
伊澤, 正一郎
加藤, 雅彦
谷口, 晋一
山本, 一博
Sumi, Keisuke
Matsumoto, Kazuhisa
Shoji, Kyoko
Nakamura, Risa
|
| 著者所属（英） |
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|
en |
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
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en |
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
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|
en |
|
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
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|
en |
|
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
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|
en |
|
|
Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
|
Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
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|
en |
|
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Department of Regional Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
|
Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 著者所属（英） |
|
|
|
en |
|
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Department of Regional Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
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|
en |
|
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Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Aims/Introduction: The aim of the present study was to evaluate the properties of the glucagon stimulation test (GST) and the normal meal tolerance test (NMTT) in patients with type 2 diabetes. Materials and Methods: We enrolled 142 patients with type 2 diabetes, and carried out a GST and a NMTT. We carried out the NMTT using a calorie-controlled meal based on an intake of 30 kcal/kg ideal bodyweight/day. We calculated the change in C-peptide immunoreactivity (ΔCPR) by subtracting fasting CPR from the CPR 6 min after the 1-mg glucagon injection (GST) or 120 min after the meal (NMTT). Results: Mean ΔCPR for the GST was 2.0 ng/mL, and for the NMTT was 3.1 ng/mL. A total of 104 patients had greater ΔCPR in the NMTT than the GST, and the mean ΔCPR was significantly greater in the NMTT than the GST (P < 0.05). To exclude any influence of antidiabetic drugs, we examined 42 individuals not taking antidiabetic agents, and found the mean ΔCPR was significantly greater in the NMTT than the GST (GST 2.4 ng/mL, NMTT 4.3 ng/mL; P < 0.05). To consider the influence of glucose toxicity, we carried out receiver operating characteristic analyses with fasting plasma glucose and glycated hemoglobin. The optimal cut-off levels predicting GST ΔCPR to be larger than NMTT ΔCPR were fasting plasma glucose 147 mg/dL and glycated hemoglobin 9.0% (fasting plasma glucose: sensitivity 0.64, specificity 0.76, area under the curve 0.73; glycated hemoglobin: sensitivity 0.56, specificity 0.71, area under the curve 0.66). Conclusions: The NMTT is a reliable insulin secretion test in patients with type 2 diabetes, except for those in a hyperglycemic state. |
| 書誌情報 |
JOURNAL OF DIABETES INVESTIGATION
en : JOURNAL OF DIABETES INVESTIGATION
巻 9,
号 2,
p. 274-278,
発行日 2018-03
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| 出版者 |
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出版者 |
WILEY |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20401116 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/jdi.12692 |
| 権利 |
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|
権利情報 |
(C) 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd J Diabetes Investig Vol. No 2017 This is an open access article under the terms of the Creati |
| 情報源 |
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関連名称 |
Fujioka Youhei, Okura Tsuyoshi, Sumi Keisuke, et al. Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity |
| 関連サイト |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12692 |
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|
関連名称 |
https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12692 |
| 著者版フラグ |
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出版タイプ |
VoR |
| EISSN |
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20401124 |
jdi9(2)_274.pdf (320.1 kB)
