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Rescue from Stx2-Producing E.?coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice
https://repository.lib.tottori-u.ac.jp/records/7313
https://repository.lib.tottori-u.ac.jp/records/7313471d8b19-6046-4733-b25a-9b6d2147dd0d
| 名前 / ファイル | ライセンス | アクション |
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mt28(1)_100.pdf (6.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-08 | |||||
| タイトル | ||||||
| タイトル | Rescue from Stx2-Producing E.?coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
尾鶴, 亮
× 尾鶴, 亮× 松葉, 隆司× 飯野, 守男× 加藤, 信介× 山下, 栄二郎× 黒沢, 洋一× 藤井, 潤× Wakao, Shohei× Tsuji, Takahiro× Ohara, Naoya× Amuran, Muhammad Y.× Isobe, Junko× Nishida, Naoki× Matsumoto, Sari× Iwadate, Kimiharu× Konishi, Noriko× Yasuda, Kaori× Tashiro, Kosuke× Hida, Misato× Yadoiwa, Arisato× Yamashita, Eijiro× Matsumoto, Sohkichi× Dezawa, Mari |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Neurology, Hasanuddin University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Bacteriology, Toyama Institute of Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Legal Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Forensic Medicine, The Jikei University School of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Forensic Medicine, The Jikei University School of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Food Microbiology, Tokyo Metropolitan Institute of Public | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Clinical Radiology, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Bacteriology, Niigata University School of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis, hemolytic uremic syndrome, and acute encephalopathies that may lead to sudden death or severe neurologic sequelae. Current treatments, including immunoglobulin G (IgG) immunoadsorption, plasma exchange, steroid pulse therapy, and the monoclonal antibody eculizumab, have limited effects against the severe neurologic sequelae. Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative non-tumorigenic stem cells that naturally reside in the body and are currently under clinical trials for regenerative medicine. When administered intravenously, Musecells accumulate to the damaged tissue, where they exert anti-inflammatory, anti-apoptotic, anti-fibrotic, and immunomodulatory effects, and replace damaged cells by differentiating into tissue-constituent cells. Here, severely immunocompromised non-obese diabetic/severe combined immunodeficiency (NOD-SCID) mice orally inoculated with 9 × 109 colony-forming units of STEC O111 and treated 48 h later with intravenous injection of 5 × 104 Muse cells exhibited 100% survival and no severe after-effects of infection. Suppression of granulocyte-colony-stimulating factor (G-CSF) by RNAi abolished the beneficial effects of Muse cells, leading to a 40% death and significant body weight loss, suggesting the involvement of G-CSF in the beneficial effects of Muse cells in STEC-infected mice. Thus, intravenous administration of Muse cells could be a candidate therapeutic approach for preventing fatal encephalopathy after STEC infection. | |||||
| 書誌情報 |
Molecular Therapy en : Molecular Therapy 巻 28, 号 1, p. 100-118, 発行日 2020-01-08 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15250016 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ymthe.2019.09.023 | |||||
| 権利 | ||||||
| 権利情報 | © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/ | |||||
| 情報源 | ||||||
| 関連名称 | Ozuru, Ryo. Wakao, Shohei. Tsuji, Takahiro. et al. Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice. Molecular Therapy. 28. 100-118. 2020-01-08. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1525001619304526 | |||||
| 関連名称 | https://www.sciencedirect.com/science/article/pii/S1525001619304526 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
