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Cortical projection to the subventricular zone and its effect on adult neurogenesis in mice
https://repository.lib.tottori-u.ac.jp/records/7316
https://repository.lib.tottori-u.ac.jp/records/7316a9834cd2-a293-4450-9f76-4b7339dac750
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nl799_137101.pdf (4.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-10 | |||||
| タイトル | ||||||
| タイトル | Cortical projection to the subventricular zone and its effect on adult neurogenesis in mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Adult neurogenesis | |||||
| キーワード | ||||||
| 主題 | Cortical projection | |||||
| キーワード | ||||||
| 主題 | Cell migration | |||||
| キーワード | ||||||
| 主題 | Injury | |||||
| キーワード | ||||||
| 主題 | Subventricular zone | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Adult neurogenesis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Cortical projection | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Cell migration | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Injury | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Subventricular zone | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
森, 徹自
× 森, 徹自× Ota, Rei× Yoshida, Ryota |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Various brain regions/nuclei project axons to the subventricular zone (SVZ), a postnatal neurogenic niche. In adults, neurogenesis is controlled by neuronal activity, via neurotransmitters. Glutamate is a major excitatory neurotransmitter, and glutamate receptors are expressed in SVZ cells. Although the cerebral cortex is a major source of glutamate and the medial cortex projects axons to the medial striatum next to the SVZ, it remains unclear whether cortical neurons regulate adult neurogenesis in vivo. First, to analyze axonal projection, plasmid vector expressing DsRed was introduced to the medial cortex by in utero electroporation. At the adult stage, DsRed-labeled axons were detected in the dorsolateral, striatal, and septal areas of the SVZ, and where they were in contact with neuroblasts. Furthermore, maturation of the cortical projection and the SVZ appeared to synchronize during postnatal stages. Next, stab injuries were made in the bilateral medial cortex to interrupt cortical input to the SVZ. At 17 days post-injury, cell proliferation in the SVZ and tangential migration of neuroblasts to the olfactory bulb were not significantly affected. There were clusters of neuroblasts in the striatum close to the SVZ in all experimental groups, but the number and size of neuroblast clusters were significantly larger in the medial cortex-injured group compared with the other experimental groups. These neuroblast clusters had a morphology of tangentially migrating cells to the olfactory bulb. These results suggest that cortical input to the SVZ inhibits the radial migration of neuroblasts to converge with the migration pathway in vivo. | |||||
| 書誌情報 |
Neuroscience Letters en : Neuroscience Letters 巻 799, p. 137101, 発行日 2023-03-16 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03043940 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neulet.2023.137101 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2023 Elsevier B.V. | |||||
| 情報源 | ||||||
| 関連名称 | Neuroscience Letters. 799, 137101, doi:10.1016/j.neulet.2023.137101 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0304394023000551 | |||||
| 関連名称 | https://www.sciencedirect.com/science/article/pii/S0304394023000551 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| EISSN | ||||||
| 値 | 18727972 | |||||
