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Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia
https://repository.lib.tottori-u.ac.jp/records/7318
https://repository.lib.tottori-u.ac.jp/records/7318f5e959e8-51a9-48dd-9e58-dafc41566aea
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nt12(11)_nu12113480.pdf (771.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-06-30 | |||||
| タイトル | ||||||
| タイトル | Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | spearmint | |||||
| キーワード | ||||||
| 主題 | rosmarinic acid | |||||
| キーワード | ||||||
| 主題 | polyphenol | |||||
| キーワード | ||||||
| 主題 | amyloid fibril | |||||
| キーワード | ||||||
| 主題 | amyloid beta | |||||
| キーワード | ||||||
| 主題 | alpha-synuclein | |||||
| キーワード | ||||||
| 主題 | Tau | |||||
| キーワード | ||||||
| 主題 | dementia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | spearmint | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | rosmarinic acid | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polyphenol | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | amyloid fibril | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | amyloid beta | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | alpha-synuclein | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Tau | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dementia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
本郷, 邦広
× 本郷, 邦広× 溝端, 知宏× 河田, 康志× Ogawa, Kenjirou× Ishii, Ayumi× Shindo, Aimi× Sogon, Tetsuya |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Organization for Promotion of Tenure Track, University of Miyazaki | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | R&D Department,Wakasa Seikatsu Co. Ltd. | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neurological dementias such as Alzheimer’s disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregates in order to prevent and/or delay the progression of dementia in these ailments. In this report, we investigated the effects of spearmint extract (SME) and rosmarinic acid (RA; the major component of SME) on the amyloid fibril formation reactions of αSyn, Aβ, and Tau proteins in vitro. SME or RA was added to soluble samples of each protein and the formation of fibrils was monitored by thioflavin T (ThioT) binding assays and transmission electron microscopy (TEM). We also evaluated whether preformed amyloid fibrils could be dissolved by the addition of RA. Our results reveal for the first time that SME and RA both suppress amyloid fibril formation, and that RA could disassemble preformed fibrils of αSyn, Aβ, and Tau into non-toxic species. Our results suggest that SME and RA may potentially suppress amyloid fibrils implicated in the progression of Alzheimer’s disease and Lewy body dementia in vivo, as well. | |||||
| 書誌情報 |
NUTRIENTS en : NUTRIENTS 巻 12, 号 11, 発行日 2020-11 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/nu12113480 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | Ogawa Kenjirou, Ishii Ayumi, Shindo Aimi, et al. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. NUTRIENTS. 2020. 12(11). doi:10.3390/nu12113480 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6643/12/11/3480 | |||||
| 関連名称 | https://www.mdpi.com/2072-6643/12/11/3480 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 20726643 | |||||
