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Inhibitory effects of local anesthetics on the proteasome and their biological actions
https://repository.lib.tottori-u.ac.jp/records/7370
https://repository.lib.tottori-u.ac.jp/records/73703ca83d52-8bbd-4d4c-bbc4-362283b02401
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
sr7_s41598-017-04652-2.pdf (4.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-15 | |||||
| タイトル | ||||||
| タイトル | Inhibitory effects of local anesthetics on the proteasome and their biological actions | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Kososan | |||||
| キーワード | ||||||
| 主題 | Recurrent depression | |||||
| キーワード | ||||||
| 主題 | Social defeat stress | |||||
| キーワード | ||||||
| 主題 | Antidepressant | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Kososan | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Recurrent depression | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Social defeat stress | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Antidepressant | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Bahrudin, Udin
× Bahrudin, Udin× 李, 佩俐× 加藤, 克× 井上, 雅史× Tsujitani, Shunichi× 山口, 博司× 河田, 康志× 伊藤, 敏幸× 二宮, 治明× 久留, 一郎× Bahrudin, Udin× Unno, Masaki× Nishio, Kazuya× Kita, Akiko× Inoue, Masashi× Tsujitani, Shunichi× Murakami, Takuto× Sugiyama, Rina× Saeki, Yasushi× Obara, Yuji× Tanaka, Keiji× Yamaguchi, Hiroshi× Sakane, Isao× Morimoto, Yukio |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Present address: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Diponegoro University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Graduate School of Science and Engineering, Ibaraki University / Frontier Research Center for Applied Atomic Sciences, Ibaraki University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Reactor Institute, Kyoto University / Present address: Graduate School of Life Science, University of Hyogo | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Reactor Institute, Kyoto University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Surgery, National Hospital Organization Kure Medical Center | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Cancer Center, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | School of Science and Technology, Kwansei Gakuin University / RIKEN SPring-8 Center, RIKEN Harima Institute | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Graduate School of Science and Engineering, Ibaraki University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Graduate School of Science and Engineering, Ibaraki University / Frontier Research Center for Applied Atomic Sciences, Ibaraki University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | School of Science and Technology, Kwansei Gakuin University / RIKEN SPring-8 Center, RIKEN Harima Institute | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biological Regulation, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Research Reactor Institute, Kyoto University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its activity. Molecular dynamic calculation indicated that these LAs were bound to the β5 subunit of the 20S proteasome, and not to the other active subunits, β1 and β2. Consistently, pilsicainide inhibited only chymotrypsin-like activity, whereas it did not inhibit the caspase-like and trypsin-like activities. In addition, we confirmed that the aromatic ring of these LAs was critical for inhibiting the proteasome. These LAs stabilized p53 and suppressed proliferation of p53-positive but not of p53-negative cancer cells. | |||||
| 書誌情報 |
SCIENTIFIC REPORTS en : SCIENTIFIC REPORTS 巻 7, 発行日 2017-07-11 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-017-04652-2 | |||||
| 権利 | ||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th | |||||
| 情報源 | ||||||
| 関連名称 | Bahrudin Udin, Unno Masaki, Nishio Kazuya, et al. Inhibitory effects of local anesthetics on the proteasome and their biological actions. SCIENTIFIC REPORTS. 2017. 7. doi:10.1038/s41598-017-04652-2 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-017-04652-2 | |||||
| 関連名称 | https://www.nature.com/articles/s41598-017-04652-2 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
