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Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats
https://repository.lib.tottori-u.ac.jp/records/7390
https://repository.lib.tottori-u.ac.jp/records/73908e0719ad-a8ab-4fc8-98cc-db53b0372dc9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
vp100_41.pdf (3.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-09-08 | |||||
| タイトル | ||||||
| タイトル | Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cardiopulmonary remodeling | |||||
| キーワード | ||||||
| 主題 | Imatinib | |||||
| キーワード | ||||||
| 主題 | Sunitinib | |||||
| キーワード | ||||||
| 主題 | Pulmonary arterial hypertension | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Cardiopulmonary remodeling | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Imatinib | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Sunitinib | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Pulmonary arterial hypertension | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
樋口, 雅司
× 樋口, 雅司× 山野, 好章× 日笠, 喜朗× Leong, Zi Ping× Okida, Ayumi |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | High-dose imatinib reverses cardiopulmonary remodeling but adverse effects limit its clinical use. Efficacy of the multi-kinase inhibitor sunitinib remains questionable. We compared anti-remodeling effects of imatinib with sunitinib on monocrotaline-induced right ventricular (RV) hypertrophy and pulmonary arterial remodeling in rats, focusing on a lower dose. Fourteen days after monocrotaline injection, oral gavage of imatinib (5, 15, or 50mg/kg), sunitinib (0.3, 1, 3, or 10mg/kg), or water for 14days was started. RV hypertrophy and b-type natriuretic peptide mRNA levels were significantly and dose-dependently reduced, much greater in imatinib- than sunitinib-treated groups. Imatinib normalized muscularization of 20–50μm intra-acinar pulmonary arteries more significantly than sunitinib. At transcript levels, sunitinib significantly upregulated pulmonary nestin, and downregulated platelet-derived growth factor receptor beta (PDGFR-β), fibroblast growth factor receptor 1, vascular endothelial growth factor receptor-2 and vascular endothelial growth factor (VEGF)-A, but not Raf-1 proto-oncogene serine/threonine kinase mRNAs. Sunitinib also suppressed VEGF-A, but not phosphorylated extra-cellular-signal-related kinase (ERK)-1/2 protein expression. The sole PDGFR-β antagonism of imatinib resulted in significant Raf-1 mRNA and phosphorylated ERK-1/2 protein downregulation, suggesting that the equivocal reversal effect of sunitinib may be due to its VEGF signaling inhibition in the lung. Imatinib's greater dose-dependent reversal on cardiopulmonary remodeling may make a low dose suitable for PAH treatment. | |||||
| 書誌情報 |
Vascular Pharmacology en : Vascular Pharmacology 巻 100, p. 41-50, 発行日 2018-01-31 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15371891 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.vph.2017.10.006 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 情報源 | ||||||
| 関連名称 | Leong, Zi Ping. Okida, Ayumi. Higuchi, Masahi. et al. Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats. Vascular Pharmacology. 100. 41-50. 2018. doi:10.1016/j.vph.201 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1537189117302148 | |||||
| 関連名称 | https://www.sciencedirect.com/science/article/pii/S1537189117302148 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
