| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-09-08 |
| タイトル |
|
|
タイトル |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cardiopulmonary remodeling |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Imatinib |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Sunitinib |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Pulmonary arterial hypertension |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cardiopulmonary remodeling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Imatinib |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sunitinib |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pulmonary arterial hypertension |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
樋口, 雅司
山野, 好章
日笠, 喜朗
Leong, Zi Ping
Okida, Ayumi
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
High-dose imatinib reverses cardiopulmonary remodeling but adverse effects limit its clinical use. Efficacy of the multi-kinase inhibitor sunitinib remains questionable. We compared anti-remodeling effects of imatinib with sunitinib on monocrotaline-induced right ventricular (RV) hypertrophy and pulmonary arterial remodeling in rats, focusing on a lower dose. Fourteen days after monocrotaline injection, oral gavage of imatinib (5, 15, or 50mg/kg), sunitinib (0.3, 1, 3, or 10mg/kg), or water for 14days was started. RV hypertrophy and b-type natriuretic peptide mRNA levels were significantly and dose-dependently reduced, much greater in imatinib- than sunitinib-treated groups. Imatinib normalized muscularization of 20–50μm intra-acinar pulmonary arteries more significantly than sunitinib. At transcript levels, sunitinib significantly upregulated pulmonary nestin, and downregulated platelet-derived growth factor receptor beta (PDGFR-β), fibroblast growth factor receptor 1, vascular endothelial growth factor receptor-2 and vascular endothelial growth factor (VEGF)-A, but not Raf-1 proto-oncogene serine/threonine kinase mRNAs. Sunitinib also suppressed VEGF-A, but not phosphorylated extra-cellular-signal-related kinase (ERK)-1/2 protein expression. The sole PDGFR-β antagonism of imatinib resulted in significant Raf-1 mRNA and phosphorylated ERK-1/2 protein downregulation, suggesting that the equivocal reversal effect of sunitinib may be due to its VEGF signaling inhibition in the lung. Imatinib's greater dose-dependent reversal on cardiopulmonary remodeling may make a low dose suitable for PAH treatment. |
| 書誌情報 |
Vascular Pharmacology
en : Vascular Pharmacology
巻 100,
p. 41-50,
発行日 2018-01-31
|
| 出版者 |
|
|
出版者 |
Elsevier |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15371891 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.vph.2017.10.006 |
| 権利 |
|
|
権利情報 |
(C) 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 情報源 |
|
|
|
関連名称 |
Leong, Zi Ping. Okida, Ayumi. Higuchi, Masahi. et al. Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats. Vascular Pharmacology. 100. 41-50. 2018. doi:10.1016/j.vph.201 |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.sciencedirect.com/science/article/pii/S1537189117302148 |
|
|
関連名称 |
https://www.sciencedirect.com/science/article/pii/S1537189117302148 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
vp100_41.pdf (3.8 MB)
