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Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression
https://repository.lib.tottori-u.ac.jp/records/4671
https://repository.lib.tottori-u.ac.jp/records/46714b15de9b-2779-4b63-a83a-3829347ae60b
| 名前 / ファイル | ライセンス | アクション |
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yam64(1)_057.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2021-03-17 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | hypoglycemia | |||||||||||
| キーワード | ||||||||||||
| 主題 | insulin/IGF-1 signaling | |||||||||||
| キーワード | ||||||||||||
| 主題 | preterm | |||||||||||
| キーワード | ||||||||||||
| 主題 | small-for-gestational age | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | hypoglycemia | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | insulin/IGF-1 signaling | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | preterm | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題 | small-for-gestational age | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
鞁嶋, 有紀
× 鞁嶋, 有紀
WEKO
1455
× 藤本, 正伸× 三浦, 真澄× 足立, 香織× 難波, 栄二× 難波, 範行× Narai, Satoshi× Fujimoto, Masanobu |
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| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University | |||||||||||
| 著者所属（英） | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | [Background] Insulin and insulin-like growth factor (IGF) signaling plays an important role in prenatal and postnatal growth and glucose metabolism. Both small-for-gestational age (SGA) and preterm infants have abnormal growth and glucose metabolism. However, the underlying mechanism remains unknown. Recently, we showed that term SGA infants have abnormal insulin/IGF signaling in cord blood. In this study, we examined whether preterm infants show similar aberrations in cord blood insulin/IGF signaling. [Methods] A total of 41 preterm cord blood samples were collected. Blood glucose, insulin, IGF-1, and C-peptide concentrations were measured, and mRNA expression of IGF1R, INSR, IRS1, IRS2, and SLC2A4 (i.e., GLUT4) was analyzed by quantitative reverse-transcription PCR. [Results] This study included 34 appropriate-for-gestational age (AGA) and 7 SGA preterm neonates. No hyperinsulinemia or any differences in IGF1R or INSR mRNA expression were detected between the two groups. However, GLUT4 mRNA levels were increased in preterm SGA. Moreover, the expression level in hypoglycemic preterm SGA was significantly higher than that in hypoglycemic preterm AGA. IRS2 mRNA expression did not show a statistically significant difference between preterm SGA and AGA neonates. [Conclusion] SGA preterm birth does not induce hyperinsulinemia; however, it modifies insulin/IGF signaling components such as GLUT4 in umbilical cord blood. Our study suggests that prematurity or adaptation to malnutrition alters the insulin/IGF signaling pathway. | |||||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 64, 号 1, p. 57-66, 発行日 2021-02-22 |
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| 出版者 | ||||||||||||
| 出版者 | Tottori University Medical Press | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 05135710 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00892882 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.33160/yam.2021.02.009 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | (C) 2021 Tottori University Medical Press | |||||||||||
| 情報源 | ||||||||||||
| 関連名称 | S. Narai, Y. Kawashima-Sonoyama, M. Fujimoto, et al. Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression. Yonago Acta Medica. 2021, 64(1), 57-66. doi:10.33160/yam.2021.02.009 | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam64-1/64-1contents.html | |||||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam64-1/64-1contents.html | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/64/1/64_2021.02.009/_article/-char/ja | |||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/64/1/64_2021.02.009/_article/-char/ja | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| EISSN | ||||||||||||
| 値 | 13468049 | |||||||||||
