| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
head and neck squamous cell carcinoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
loss of imprinting |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PEG1/MEST |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
head and neck squamous cell carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
loss of imprinting |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PEG1/MEST |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Kataoka, Hideyuki
Nakano, Seiji
Kunimoto, Yasuomi
Sugie, Naoko
Osaki, Mitsuhiko
Uzawa, Narikazu
Yoshida, Mitsuaki A.
Oshimura, Mitsuo
Kitano, Hiroya
Nakano, Seiji
Sugie, Naoko
Uzawa, Narikazu
Yoshida, Mitsuaki A.
Kitano, Hiroya
|
| 著者所属 |
|
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University |
| 著者所属 |
|
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University |
| 著者所属 |
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|
値 |
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University |
| 著者所属 |
|
|
値 |
Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University |
| 著者所属 |
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|
値 |
Biodosimetry Section, Department of Radiation Dosimetry, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences |
| 著者所属 |
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|
値 |
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University |
| 著者所属 |
|
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript PEG1/MEST, in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 52,
号 2,
p. 85-90,
発行日 2009-06
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| 出版者 |
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出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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|
関連名称 |
Yonago Acta medica. 2009, 52(2), 85-90 |
| 著者版フラグ |
|
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出版タイプ |
VoR |
52_085-090.pdf (152.9 kB)
