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Expression of phospho-Akt and PTEN Proteins Predicts the Survival of Patients with Pancreatic Cancer
https://repository.lib.tottori-u.ac.jp/records/5064
https://repository.lib.tottori-u.ac.jp/records/5064bad381a9-9420-4d5f-961d-ace3c8ea6f00
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
49_009-017.pdf (489.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Expression of phospho-Akt and PTEN Proteins Predicts the Survival of Patients with Pancreatic Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | pancreatic cancer | |||||
| キーワード | ||||||
| 主題 | phosphatase and tensin homologue deleted on chromosome ten | |||||
| キーワード | ||||||
| 主題 | phosphorylated-Akt | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | pancreatic cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | phosphatase and tensin homologue deleted on chromosome ten | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | phosphorylated-Akt | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ozaki-Ohgami, Yoshimi
× Ozaki-Ohgami, Yoshimi× Iwamoto, Akemi× Yoshioka, Shizue× Tatebe, Shigeru× Hirooka, Yasuaki× Ikeguchi, Masahide× Ozaki-Ohgami, Yoshimi× Iwamoto, Akemi× Yoshioka, Shizue× Tatebe, Shigeru |
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| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The phosphatidylinositol-3 kinase (PI3K)-Akt signaling pathway is known to protect a variety of cells from apoptosis. Phospho-Akt (p-Akt) can facilitate cell survival and inactivating pro-apoptotic proteins. The phosphatase and tensin homologue deleted on chromosome ten (PTEN) is a natural biological inhibitor of p-Akt in the PI3K-Akt pathway. The relationship between the expressions of p-Akt and PTEN and pancreatic cancer is unknown. Here, we designed a study to clarify the prognostic significance of p-Akt and PTEN expression in patients with pancreatic cancer. Immunohistochemical analysis of p-Akt and PTEN protein was performed on 51 specimens of pancreatic cancer. The expression of p-Akt was detected in 32 patients (62.7%). The expression of p-Akt was frequently detected in patients with advanced stage pancreatic cancer (P = 0.0233). Patients with p-Akt-positive tumors had significantly worse prognoses than those with p-Akt-negative tumors (overall survival; 11.3% versus 25.7%). The expression of PTEN was detected in 26 patients (51.0%). Patients with PTEN-positive tumors had significantly better prognoses than those with PTEN-negative tumors (overall survival; 29.9% versus 0%). Patients with p-Akt-positive and PTEN-negative tumors had significantly worse prognoses than those with p-Akt-negative and PTEN-positive tumors (overall survival; 0% versus 39.1%). Multivariate analysis revealed that expression of p-Akt was an independent prognostic factor as well as arterial invasion and lymph node metastasis. The expression of p-Akt and PTEN proteins determined by immunohistochemistry may be a new method for predicting the prognosis of patients with pancreatic cancer. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 1, p. 9-17, 発行日 2006-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2006, 49(1), 9-17 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
