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Effects of Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase (eNOS) Gene on eNOS mRNA and Protein Expressions in Cultured Human Vascular Endothelial Cells
https://repository.lib.tottori-u.ac.jp/records/5069
https://repository.lib.tottori-u.ac.jp/records/5069ce7cef99-8b7a-4c77-b4e9-854611a74f08
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
49_059-062.pdf (124.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effects of Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase (eNOS) Gene on eNOS mRNA and Protein Expressions in Cultured Human Vascular Endothelial Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | gene expression | |||||
| キーワード | ||||||
| 主題 | nitric oxide synthase | |||||
| キーワード | ||||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 主題 | vascular endothelial cell | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | gene expression | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nitric oxide synthase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | vascular endothelial cell | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kishimoto, Takuji
× Kishimoto, Takuji× Kaetsu, Akihiko× Osaki, Yoneatsu× Okamoto, Mikizoh× Nagai, Mariya× Kurosawa, Yoichi× Yoshida, Soichi× Nagai, Mariya× Yoshida, Soichi |
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| 著者所属 | ||||||
| 値 | Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Environmental and Preventive Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Health Administration and Promotion, Department of Social Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Reproductive-Perinatal Medicine and Gynecologic Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The relationship between cardiovascular disease and Glu298Asp polymorphism of nitric oxide synthase (eNOS) gene in vascular endothelial cells is controversial due to conflicting results. To demonstrate the effects of Glu298Asp polymorphism of the eNOS gene on eNOS gene expression by excluding the effects of various confounding factors, eNOS mRNA and protein expressions were measured using cultured human umbilical vein endothelial cells (HUVECs) according to genotypes of Glu298Asp polymorphism of the eNOS gene. eNOS mRNA expression was measured by real-time PCR/reverse trasnscription-PCR. eNOS protein expression was measured by an immunoassay method. HUVECs with Glu298Asp tended to show higher eNOS mRNA and protein expressions than those with Glu298Glu, but the difference was not significant. These results suggest that the genotypic difference of Glu298Glu and Glu298Asp has no effect on eNOS mRNA and protein expressions. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 1, p. 59-62, 発行日 2006-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2006, 49(1), 59-62 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
