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Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats
https://repository.lib.tottori-u.ac.jp/records/5105
https://repository.lib.tottori-u.ac.jp/records/51052250edb3-8b72-4810-a086-2c11c200c191
名前 / ファイル | ライセンス | アクション |
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Yonago Acta medica 編集委員会
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | angiotensin-converting-enzyme inhibitor | |||||
キーワード | ||||||
主題 | cytokine | |||||
キーワード | ||||||
主題 | interleukin-6 | |||||
キーワード | ||||||
主題 | lipopolysaccharide | |||||
キーワード | ||||||
主題 | spleen | |||||
キーワード | ||||||
言語 | en | |||||
主題 | angiotensin-converting-enzyme inhibitor | |||||
キーワード | ||||||
言語 | en | |||||
主題 | cytokine | |||||
キーワード | ||||||
言語 | en | |||||
主題 | interleukin-6 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | lipopolysaccharide | |||||
キーワード | ||||||
言語 | en | |||||
主題 | spleen | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Watanabe, Tatsuo
× Watanabe, Tatsuo× Miyoshi, Michio× Nagata, Katsumi× Imoto, Toshiaki |
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著者所属 | ||||||
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | ||||||
著者所属 | ||||||
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiotensin II (ANG II) has been shown to have proinflammatory properties. To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats. | |||||
書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 2, p. 49-55, 発行日 2003-06 |
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出版者 | ||||||
出版者 | Tottori University Faculty of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468049 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00892882 | |||||
権利 | ||||||
権利情報 | Yonago Acta medica 編集委員会 | |||||
情報源 | ||||||
関連名称 | Yonago Acta medica. 2003, 46(2), 49-55 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |