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Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats
https://repository.lib.tottori-u.ac.jp/records/5105
https://repository.lib.tottori-u.ac.jp/records/51052250edb3-8b72-4810-a086-2c11c200c191
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_049-055.pdf (54.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | angiotensin-converting-enzyme inhibitor | |||||
| キーワード | ||||||
| 主題 | cytokine | |||||
| キーワード | ||||||
| 主題 | interleukin-6 | |||||
| キーワード | ||||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 主題 | spleen | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | angiotensin-converting-enzyme inhibitor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cytokine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | interleukin-6 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | spleen | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Watanabe, Tatsuo
× Watanabe, Tatsuo× Miyoshi, Michio× Nagata, Katsumi× Imoto, Toshiaki |
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| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Angiotensin II (ANG II) has been shown to have proinflammatory properties. To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 2, p. 49-55, 発行日 2003-06 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2003, 46(2), 49-55 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
