| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
angiotensin-converting-enzyme inhibitor |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
interleukin-6 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
lipopolysaccharide |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
spleen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
angiotensin-converting-enzyme inhibitor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interleukin-6 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lipopolysaccharide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
spleen |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Watanabe, Tatsuo
Miyoshi, Michio
Nagata, Katsumi
Imoto, Toshiaki
|
| 著者所属 |
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|
値 |
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Angiotensin II (ANG II) has been shown to have proinflammatory properties. To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 46,
号 2,
p. 49-55,
発行日 2003-06
|
| 出版者 |
|
|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
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|
関連名称 |
Yonago Acta medica. 2003, 46(2), 49-55 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
46_049-055.pdf (54.3 kB)
