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To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 2003, 46(2), 49-55"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", 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Tottori University Faculty of Medicine"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Tatsuo"}, {"creatorName": "Watanabe, Tatsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4183", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60182929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60182929"}, {"nameIdentifier": "100000290", "nameIdentifierScheme": "研究者総覧鳥取大学", "nameIdentifierURI": "http://researchers.adm.tottori-u.ac.jp/html/100000290_ja.html"}]}, {"creatorNames": [{"creatorName": "Miyoshi, Michio"}, {"creatorName": "Miyoshi, Michio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2222", 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"Other"}, {"subitem_subject": "lipopolysaccharide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spleen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "angiotensin-converting-enzyme inhibitor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytokine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-6", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lipopolysaccharide", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spleen", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": 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