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A Case of Nephrotic Syndrome with Nephrotoxicity Induced by Low-Dose Cyclosporin Treatment
https://repository.lib.tottori-u.ac.jp/records/5179
https://repository.lib.tottori-u.ac.jp/records/51792376a2a0-61ca-49c7-be75-242d4c08ac45
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
42_125-130.pdf (117.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | A Case of Nephrotic Syndrome with Nephrotoxicity Induced by Low-Dose Cyclosporin Treatment | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | cyclosporin | |||||
| キーワード | ||||||
| 主題 | nephrotic syndrome | |||||
| キーワード | ||||||
| 主題 | nephrotoxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cyclosporin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nephrotic syndrome | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nephrotoxicity | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Utsunomiya, Yasushi
× Utsunomiya, Yasushi× Konishi, Kyoko× Okada, Shin-ichi× Sasaki, Yoshihiro× Hayashi, Atsushi× Nakagawa, Takako× Kasagi, Tsunakiyo× Shiraki, Kazuo× Utsunomiya, Yasushi× Konishi, Kyoko× Sasaki, Yoshihiro× Hayashi, Atsushi× Nakagawa, Takako |
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| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Nursing, Institute of Medical Care Technology, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatrics, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We report a 3-year-old girl with steroid resistant nephrotic syndrome (NS) who developed nephrotoxicity by low-dose cyclosporin (CsA) treatment. Initial prednisolone (PSL) treatment and subsequent additional cyclophosphamide treatment were not successful in leading her into remission. The first renal biopsy finding revealed neither a glomerular nor interstitial change. CsA therapy was initiated in addition to ongoing glucocorticoid therapy at 6 months from the time of onset. Proteinuria disappeared 3 weeks later and the patient went into complete remission. After experiencing the first relapse, the patient was gradually weaned from CsA, and treatment continued with 30 to 50 ng/mL of trough concentration. No elevations of the serum creatinine, serum urea, serum potassium, excretion of urinary β2-microglobulin, or urinary N-acetyl-β-D-glucosaminidase were demonstrated in the follow-up. A second renal biopsy specimen obtained 1 year later showed a tubulo-interstitial change, containing tubular atrophy and interstitial fibrosis, both of which are consistent with the morphological change associated with CsA nephrotoxicity. A follow-up biopsy should be done in order to evaluate the CsA nephrotoxicity, regardless of the treatment dosage. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 42, 号 1, p. 125-130, 発行日 1999-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1999, 42(1), 125-130 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
