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AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する
https://repository.lib.tottori-u.ac.jp/records/5843
https://repository.lib.tottori-u.ac.jp/records/5843937c82d7-ecd7-4175-be0c-d77b55b45a67
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (1.1 MB)
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要旨 : Summary (526.7 kB)
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審査結果要旨 : Summary of Thesis Review (490.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Aberrant expression of AID and AID activators of NF-kB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | activation-induced cytidine deaminase | |||||
| キーワード | ||||||
| 主題 | Epstein-Barr virus-associated gastric cancer | |||||
| キーワード | ||||||
| 主題 | nuclear factor κB | |||||
| キーワード | ||||||
| 主題 | paired box 5 | |||||
| キーワード | ||||||
| 主題 | c-Myb proto-oncogene | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | activation-induced cytidine deaminase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Epstein-Barr virus-associated gastric cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nuclear factor κB | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | paired box 5 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | c-Myb proto-oncogene | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
毛利, 崇
× 毛利, 崇× Mori, Takashi |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Epstein‑Barr virus‑associated gastric carcinoma (EBVaGC) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma‑like histology. Aberrant expression of activation‑induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen‑related nuclear factor κB (NF‑κB) signaling in Helicobacter pylori‑associated gastric cancer. To elucidate whether or not AID expression is relevant to carcinogenesis in EBVaGC, immunohistochemical expression of AID and AID‑regulatory factors between EBVaGC and EBV‑non‑associated gastric carcinoma (GC) were evaluated, each using 15 cases of GC with lymphoid stroma (GCLS) and other types of GC. Aberrant expression of AID, NF‑κB and paired box 5 (PAX5) were significantly decreased in EBVaGC (0/11, 1/11 and 1/11) compared with in EBV‑non‑associated GC (7/19, 12/19 and 11/19) (P=0.025, 0.005 and 0.01, respectively); however, no significant difference in c‑Myb proto‑oncogene expression was identified. AID expression was also decreased in EBV‑associated GCLS (0/10) compared with in EBV‑non‑associated GCLS (3/5). Unexpectedly, decreased expression of NF‑κB and PAX5 was observed in GCLS (1/15 and 2/15) compared with in GC without LS (12/15 and 10/15) (P<0.001 and P=0.003, respectively). Decreased AID expression observed in EBVaGC is consistent with the reported molecular characterization of hypermethylation and rare somatic gene mutation in EBVaGC. Only PAX5 was identified to be significantly associated with venous invasion (P=0.022). The results of the present study suggest that pathogen‑induced AID expression may be irrelevant to carcinogenesis of EBVaGC, whereas it contributes to carcinogenesis in certain types of EBV‑non‑associated GC. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-09-30 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第859号 | |||||
| 権利 | ||||||
| 権利情報 | © Mohri et al. This is an open access article distributed under the terms of Creative Commons Attribution License: CC-BY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by Spandidos Publications: Mohri, T., Nagata, K., Kuwamoto, S., Matsushita, M., Sugihara, H., Kato, M. ... Hayashi, K. (2017). Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gast | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://spandidos-publications.com/ol/13/6/4133 | |||||
| 関連名称 | https://spandidos-publications.com/ol/13/6/4133 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
