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内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸はストレスによって誘導される行動と炎症の応答性を減弱させる
https://repository.lib.tottori-u.ac.jp/records/5869
https://repository.lib.tottori-u.ac.jp/records/58698d8c1417-062b-42f5-a027-a83ec1952e06
| 名前 / ファイル | ライセンス | アクション |
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本文 : Full Text (2.7 MB)
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要旨 : Summary (522.1 kB)
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審査結果要旨 : Summary of Thesis Review (479.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | 内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸はストレスによって誘導される行動と炎症の応答性を減弱させる | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
山梨, 豪彦
× 山梨, 豪彦× Yamanashi, Takehiro |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant and anti-inflammatory effects of BHB on rats exposed to acute and chronic stress. We examined the influence of repeated BHB administration on depressive and anxiety behaviors in a rodent model of chronic unpredictable stress (CUS). Additionally, the influence of acute immobilization (IMM) stress and single BHB administration on hippocampal interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were assessed. Repeated administration of BHB attenuated CUS-induced depressive- and anxiety-related behaviors. IMM stress increased levels of IL-1β in the hippocampus, while a single pre-administration of BHB attenuated this increase. Although no effect was observed on hippocampal TNF-α levels after 1?h of IMM stress, a single BHB pre-administration reduced hippocampal TNF-α. Our previous report showed that the release of IL-1β and TNF-α caused by stress is tightly regulated by NLRP3 inflammasome. These findings demonstrate that BHB exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hippocampus, and that BHB may be a novel therapeutic candidate for the treatment of stress-related mood disorders. | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 15101 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鳥取大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第877号 | |||||
| 権利 | ||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th | |||||
| 情報源 | ||||||
| 関連名称 | This research was published by Scientific Reports: YAMANASHI, Takehiko, et al. Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. Scientific reports, 2017, 7.1: 7677. https://d | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/articles/s41598-017-08055-1 | |||||
| 関連名称 | http://www.nature.com/articles/s41598-017-08055-1 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
