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Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
https://repository.lib.tottori-u.ac.jp/records/7340
https://repository.lib.tottori-u.ac.jp/records/734003af0f18-a26e-4477-8506-8a2456bf7f2d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
pnas105(9)_3581.pdf (4.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-01-08 | |||||
| タイトル | ||||||
| タイトル | Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | astrocytes | |||||
| キーワード | ||||||
| 主題 | cell fate | |||||
| キーワード | ||||||
| 主題 | cerebral cortex | |||||
| キーワード | ||||||
| 主題 | stem cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | astrocytes | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cell fate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cerebral cortex | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | stem cells | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Buffo, Annalisa
× Buffo, Annalisa× Rite, Inmaculada× Tripathi, Pratibha× Lepier, Alexandra× Colak, Dilek× Horn, Ana-Paula× Mori, Tetsuji× Götz, Magdalena |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health / Institute of Physiology, University of Munich | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute of Physiology, University of Munich | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Biochemistry, Federal University of Rio Grande do Sul | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein (GFAP). Whereas mature astrocytes do not normally divide, a subpopulation of the reactive GFAP+ cells does so, prompting the question of whether the proliferating GFAP+ cells arise from endogenous glial progenitors or from mature astrocytes that start to proliferate in response to brain injury. Here we show by genetic fate mapping and cell type-specific viral targeting that quiescent astrocytes start to proliferate after stab wound injury and contribute to the reactive gliosis and proliferating GFAP+ cells. These proliferating astrocytes remain within their lineage in vivo, while a more favorable environment in vitro revealed their multipotency and capacity for self-renewal. Conversely, progenitors present in the adult mouse cerebral cortex labeled by NG2 or the receptor for the platelet-derived growth factor (PDGFRα) did not form neurospheres after (or before) brain injury. Taken together, the first fate-mapping analysis of astrocytes in the adult mouse cerebral cortex shows that some astrocytes acquire stem cell properties after injury and hence may provide a promising cell type to initiate repair after brain injury. | |||||
| 書誌情報 |
PNAS : proceedings of the National Academy of Sciences of the United States of America en : PNAS : proceedings of the National Academy of Sciences of the United States of America 巻 105, 号 9, p. 3581-3586, 発行日 2008-03-04 |
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| 雑誌内区分 | ||||||
| 値 | RESEARCH ARTICLE | |||||
| 出版者 | ||||||
| 出版者 | National Academy of Sciences | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10916490 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11726874 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1073/pnas.0709002105 | |||||
| 権利 | ||||||
| 権利情報 | © 2008 by The National Academy of Sciences of the USA | |||||
| 情報源 | ||||||
| 関連名称 | Annalisa Buffo, Inmaculada Rite, Pratibha Tripathi, Alexandra Lepier, Dilek Colak, Ana-Paula Horn, Tetsuji Mori, Magdalena Götz. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proceedings of the National Academ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.pnas.org/content/105/9/3581 | |||||
| 関連名称 | https://www.pnas.org/content/105/9/3581 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
